Tag: methods
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Can acute COVID-19 awaken dormant cancer cells?
Yes, according to this study, which was the talk of the summer. In short: In mice experimental lung infection with SARS-CoV-2 and influenza reactivated dormant breast cancer cells, rapidly leading to metastatic disease accompanied by an inflammatory response resembling acute COVID-19 infection in humans. And when translated from mice to…
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Control yourself: the self-controlled case series
Does influenza increase the risk of acute myocardial infarction (AMI)? Do bivalent mRNA COVID-19 vaccines cause acute ischemic stroke? Relevant questions, but difficult to answer. Incidences of both outcomes are low, precluding an answer from randomised trials (in case of vaccination) and analyses from observational studies will be flawed by…
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Is the clinical trials enterprise broken?
Last week, I had the privilege to attend JAMA’s first ever summit in which two questions were addressed: ‘Is the clinical trials enterprise broken?’ and ‘How can it be fixed?’. The first question is rhetorical.