Tag: ventilator-associated pneumonia

  • Nebulized amikacin and VAP prevention (part 2): the art of circular reasoning

    Nebulized amikacin and VAP prevention (part 2): the art of circular reasoning

    Three months ago, a French investigator-initiated, multicenter, double-blind, randomized, placebo-controlled study reported that nebulized amikacin reduced the occurrence of VAP. Positive cultures of endotracheal aspirates were part of (the few) diagnostic criteria for VAP. My response was that “the possibility of artificial sterilization of microbiological cultures through nebulized amikacin is…

  • Nebulized amikacin: preventing positive cultures or VAP?

    Nebulized amikacin: preventing positive cultures or VAP?

    An impressive French study evaluating the effects of nebulized amikacin on the occurrence of ventilator-associated pneumonia (VAP) brought back old memories and a reminder that science moves slowly.